Evaluation of Serum Zinc Level among Hemodialysis Sudanese Patients with Erythropoietin Resistant

Authore(s) : Amal Elbadri || Department of Clinical ChemistryFaculty of Medical Laboratory SciencesAlneelien University – KhartoumSudan.

Volume : (13), Issue : 205, February - 2018

Abstract : Background: Anemia is principle health problem in patients with chronic renal failure on hemodialysis treatment  and  erythropoietin  is  treatment  of  choice, some patients do not respond as expected. Various researches  suggest  that  zinc  may  play  a  role  in  the etiology of erythropoietin resistant anemia. Objectives: To assess serum zinc level in erythropoietin resistant hemodialysis Sudanese patients and its relation to hemoglobin and comparison with apparently non erythropoietin resistant hemodialysis control patients. Materials  and  methods:  Case  control  study  was performed in Khartoum state at kidney disease clinic Khartoum Sudan, during the period from February to October 2018. 50 samples were collected from erythropoietin resistant Hemodialysis patients test group. In addition to other 50 from non-erythropoietin resistant hemodialysis   patient’s  sex   and   age   matched   control group.  The  levels  of  serum  zinc  elements  were determined in both groups by atomic absorption spectroscopy, and hemoglobin was measured by colorimetric method. Results: Serum zinc level was significantly lower in erythropoietin resistant hemodialysis patients when compared with non-erythropoietin resistant hemodialysis patients control group (0.26 ± 0.08 mg/L versus 0.67 ±0.09 mg/L). Furthermore Hb was significantly decreased (8.56 ± 0.56 gm/L versus 11.34 ± 0.59 gm/dl, p=0.000). In addition the study observed no significant difference in zinc level and hemoglobin across gender (P>0.05) in the test group. Also the study recorded serum zinc level is significantly correlated with Hb (R=0.58, P=0.00) and inversely correlated with age (R=-43, P=0.01). Whereas Hb level is insignificantly correlated with patients age in the study group (R=0.24, p=0.16). Conclusion:     Erythropoietin      resistant      anemia      in hemodialysis patients is associated with reduced serum zinc level. Which provide evidence that serum zinc levels should be measure especially in hemodialysis patients resistant to erythropoietin therapy.

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Article No : 10090

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References :

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